Sodium Butyrate ma ọ bụ tributyrin'kedu nke ị ga-ahọrọ'?

A maara nke ọma na butyric acid bụ isi iyi ike dị mkpa maka mkpụrụ ndụ colonic. Ọzọkwa, ọ bụ n'ezie isi iyi mmanụ kachasị mma ma na-enye ihe ruru 70% nke mkpa ike ha niile. Agbanyeghị, enwere ụdị abụọ ịhọrọ. Isiokwu a na-enye ntụnyere nke ha abụọ, na-enyere aka ịza ajụjụ 'kedu nke ị ga-ahọrọ'?

A mụọla ma jiri butyrates mee ihe dị ka ihe mgbakwunye nri n'ọrụ ugbo anụmanụ ruo ọtụtụ iri afọ, a na-ejikarị ya eme ihe na ụmụ ehi iji kpalite mmepe rumen n'oge tupu a chọpụta na e ji ya eme ezì na anụ ọkụkọ.

Ihe mgbakwunye Butyrate egosila na ha na-eme ka ibu ahụ dịkwuo mma (BWG) na ọnụego mgbanwe nri (FCR), na-ebelata ọnwụ ma na-ebelata mmetụta nke ọrịa ndị metụtara afọ.

Isi mmalite butyric acid a na-ahụkarị maka nri anụmanụ na-abịa n'ụdị abụọ:

1. Dịka nnu (dịka sodium butyrate) ma ọ bụ
2. N'ụdị triglyceride (dịka ọmụmaatụ Tributyrin).

Mgbe ahụ ajụjụ na-esote na-abịa -Kedu nke m ga-ahọrọ?Isiokwu a na-enye ntụnyere n'akụkụ nke ha abụọ.

Usoro mmepụta

Sodium butyrate:A na-emepụta ya site na mmeghachi omume acid-base iji mepụta nnu nwere ebe agbaze dị elu.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Mmiri)

Tributyrin:A na-emepụta ya site na esterification ebe a na-ejikọ butyric acid atọ na glycerol iji mepụta tributyrin. Tributyrin nwere obere ebe agbaze.

C3H8O3+3C4H8O2=C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Mmiri)

Kedu nke na-enye acid butyric karịa kwa kilogram ngwaahịa?

Site naTebụl 1, anyị maara ọnụọgụgụ butyric acid dị na ngwaahịa dị iche iche. Agbanyeghị, anyị kwesịkwara ịtụle otu ngwaahịa ndị a si ewepụta butyric acid n'ime eriri afọ nke ọma. Ebe ọ bụ na sodium butyrate bụ nnu, ọ ga-agbaze ngwa ngwa na mmiri na-ewepụta butyrate, ya mere anyị nwere ike iche na 100% nke butyrate sitere na sodium butyrate ga-apụta mgbe agbazere ya. Ka sodium butyrate na-ekewapụ ngwa ngwa, ụdị echekwara (ya bụ obere encapsulation) nke sodium butyrate ga-enyere ya aka inweta mwepụta butyrate nwayọ nwayọ n'ime eriri afọ ruo na eriri afọ.

Tributyrin bụ triacylglyceride (TAG), nke bụ ester sitere na glycerol na abụba atọ. Tributyrin chọrọ lipase iji wepụta butyrate ejikọtara na glycerol. Ọ bụ ezie na otu tributyrin nwere butyrate atọ, ọ bụghị butyrate atọ niile ka a ga-ahapụ. Nke a bụ n'ihi na lipase bụ regioselective. Ọ nwere ike hydrolyze triacylglycerides na R1 na R3, naanị R2, ma ọ bụ na-abụghị kpọmkwem. Lipase nwekwara nkọwapụta substrate n'ihi na enzyme nwere ike ịmata ọdịiche dị n'etiti acyl chains ejikọtara na glycerol na nkewa ụfọdụ ụdị. Ebe ọ bụ na tributyrin chọrọ lipase iji wepụta butyrate ya, enwere ike inwe asọmpi n'etiti tributyrin na TAG ndị ọzọ maka lipase.

Sodium butyrate na tributyrin ọ̀ ga-emetụta oriri nri?

Sodium butyrate nwere isi ọjọọ nke na-adịghị atọ mmadụ ụtọ mana anụmanụ na-enwe mmasị na ya. Sodium butyrate bụ 3.6-3.8% nke abụba mmiri ara ehi dị na mmiri ara ehi, ya mere, ọ nwere ike ịrụ ọrụ dị ka ihe na-adọta nri na-akpali mmụọ ndụ nke anụmanụ na-azụlite (Tebụl nke AbụọAgbanyeghị, iji hụ na mwepụta ngwa ngwa n'ime eriri afọ, a na-ejikarị ihe mkpuchi abụba (dịka Palm stearin) kpuchie sodium butyrate. Nke a na-enyekwa aka belata isi ọjọọ nke sodium butyrate.

N'aka nke ọzọ, Tributyrin enweghị isi mana ọ na-eme ka ọ na-afụ ụfụ (Tebụl nke Abụọ). Ịtinye nnukwu ego nwere ike inwe mmetụta ọjọọ na oriri nri. Tributyrin bụ molekul kwụsiri ike n'okike nke nwere ike ịgafe n'ime eriri afọ elu ruo mgbe lipase gbawara ya n'ime eriri afọ. Ọ naghịkwa agbanwe agbanwe n'ọnọdụ okpomọkụ ụlọ, yabụ a naghị ekpuchi ya n'ozuzu ya. Tributyrin na-ejikarị silica dioxide eme ihe dị ka ihe na-ebu ya. Silica dioxide nwere oghere ma ọ nwere ike ọ gaghị ewepụta tributyrin kpamkpam n'oge nri. Tributyrin nwekwara nrụgide uzuoku dị elu nke na-eme ka ọ na-agbanwe agbanwe mgbe a na-ekpo ọkụ. Ya mere, anyị na-akwado ka ejiri tributyrin mee ihe ma n'ụdị emulsified ma ọ bụ n'ụdị echekwara.