Ihe mgbakwunye nri: Tributyrin

Ọdịnaya: 95%, 90%

Tributyrin dị ka ihe mgbakwunye nri iji mee ka ahụike afọ dịkwuo mma n'anụ ọkụkọ.

Iwepụ ọgwụ nje dịka ihe na-akwalite uto site na usoro nri anụ ọkụkọ emeela ka mmasị maka usoro nri ọzọ dịkwuo elu, maka ịbawanye arụmọrụ anụ ọkụkọ yana ichebe megide nsogbu ọrịa.

Ibelata ihe mgbu na dysbacteriosis
Iji lebara ọnọdụ dysbacteriosis anya, a na-etinye ihe mgbakwunye nri dị ka probiotics na prebiotics iji metụta mmepụta nke SCFAs, ọkachasị butyric acid nke na-arụ ọrụ dị mkpa n'ichebe iguzosi ike n'ezi ihe nke eriri afọ. Butyric acid bụ SCFA sitere n'okike nke nwere ọtụtụ mmetụta bara uru dị iche iche dịka mmetụta mgbochi mkpali ya, mmetụta ya na-eme ka usoro ndozi eriri afọ dị ngwa ma na-akpali mmepe eriri afọ villi. E nwere ụzọ pụrụ iche butyric acid si arụ ọrụ site na usoro iji gbochie ọrịa, ya bụ Host Defense Peptides (HDPs), nke a makwaara dị ka anti-microbial peptides, bụ ihe dị mkpa nke mgbochi nje. Ha nwere ọrụ mgbochi nje bacteria sara mbara megide nje bacteria, fungi, nje na nje virus ndị e tinyere n'ime nke na-esiri ndị ọrịa ike iguzogide. Defensins (AvBD9 & AvBD14) na Cathelicidins bụ ezinụlọ abụọ bụ isi nke HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) a na-ahụ n'anụ ọkụkọ nke mgbakwunye butyric acid na-akwalite. Na nnyocha nke Sunkara et. al. mere. Ntinye butyric acid n'èzí na-ebute mmụba dị ịrịba ama na ngosipụta mkpụrụ ndụ ihe nketa HDP ma si otú a na-eme ka ikike iguzogide ọrịa dịkwuo mma n'ime ọkụkọ. Ihe na-adọrọ mmasị bụ na obere na LCFAs dị obere.

Uru ahụike nke Tributyrin
Tributyrin bụ ihe na-ebute butyric acid nke na-enye ohere ka ọtụtụ molekul butyric acid banye n'ime obere eriri afọ ozugbo n'ihi usoro esterification. N'ihi ya, njupụta ya dị okpukpu abụọ ruo atọ karịa nke ngwaahịa a kpuchiri ekpuchi. Esterification na-enye ohere ka molekul butyric acid atọ jikọọ na glycerol nke naanị lipase pancreas endogenous nwere ike imebi.
Li na ndị otu ya hiwere ọmụmụ ihe gbasara immunological iji chọpụta uru nke tributyrin nwere na cytokines pro-inflammatory na broilers ndị nwere LPS (lipopolysaccharide). A maara nke ọma na ojiji LPS na-akpata mbufụt na ọmụmụ ihe dịka nke a ebe ọ na-eme ka ihe nrịbama mkpali dị ka IL (Interleukins) rụọ ọrụ. N'ụbọchị 22, 24, na 26 nke nnwale ahụ, a mara broilers aka site na inye 500 μg/kg BW LPS ma ọ bụ saline n'ime peritoneal. Ntinye nri tributyrin nke 500 mg/kg gbochiri mmụba nke IL-1β & IL-6, nke na-egosi na mgbakwunye ya nwere ike ibelata ntọhapụ nke cytokines pro-inflammatory ma si otú a belata mbufụt afọ.

Nchịkọta
Site na iji ọgwụ nje ụfọdụ eme ihe ma ọ bụ mmachibido iwu zuru oke na ụfọdụ ndị na-akwalite uto ọgwụ nje dị ka ihe mgbakwunye nri, a ga-enyocha atụmatụ ọhụrụ maka imeziwanye na ichekwa ahụike nke anụmanụ ugbo. Ezi afọ na-eje ozi dị ka njikọ dị mkpa n'etiti ihe ndị dị oke ọnụ maka nri na nkwalite uto na broilers. A maara Butyric acid karịsịa dị ka ihe na-akwalite ahụike afọ nke ejirila mee ihe na nri anụmanụ ihe karịrị afọ 20. Tributyrin na-enye butyric acid n'ime obere eriri afọ ma na-arụ ọrụ nke ọma n'imetụta ahụike eriri afọ site n'ime ka usoro ndozi eriri afọ dị ngwa, na-agba ume mmepe villi kacha mma na ịgbanwe mmeghachi omume ahụ ji alụso ọrịa ọgụ na eriri afọ.

Ugbu a, ebe a na-ewepụ ọgwụ nje ahụ, butyric acid bụ ngwá ọrụ dị mma iji kwado ụlọ ọrụ ahụ iji belata mmetụta ọjọọ nke dysbacteriosis nke na-apụta n'ihi mgbanwe a.