A chọrọ ihe ọzọ a ga-eji agwọ ọrịa nje n'ihi mmachibido iji ọgwụ ndị a eme ihe dị ka ihe na-akwalite uto n'imepụta anụmanụ nri. Tributyrin yiri ka ọ na-arụ ọrụ n'ime ka uto ezì dịkwuo mma, n'agbanyeghị na ọ nwere ike ịdị irè dị iche iche.

Ruo ugbu a, a maghị ihe dị ukwuu gbasara mmetụta ya na nhazi nke microbiota eriri afọ. N'ọmụmụ ihe a, anyị nyochara mgbanwe microbiota eriri afọ nke ụmụ ezi na-anata, mgbe a na-ahapụ nwa ara, 0.2% tributyrin agbakwunyere na nri ha.

Òtù Tributyrin nwere ike ime ka metabolism ike dịkwuo mma ma belata ohere maka metabolism carbohydrate. Na mmechi, nsonaazụ anyị gosiri na tributyrin nwere ike ịkwalite mgbanwe na mpaghara nje bacteria n'afọ, nke nwere ike inye aka melite arụmọrụ anụmanụ mgbe a hapụchara ya ara.

Mmetụta nke Tributyrin na Mgbanwe nke Microbiota Gut na Ọrụ nke Ịhapụ Ezé

Usoro Ngwaahịa

Tributyrin (a na-akpọkwa ya Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate) bụ ụdị obere eriri abụba acid ester.

CAS RN: 60-01-5

Nọmba EINECS: 200-451-5

Nhazi: C15H26O6

FW: 302.36

Ọdịdị: Ọ na-acha ọcha ruo odo odo, ọ na-esikwa obere abụba.

Mmiri: a na-agbaze na ethanol, chloroform na ether, ọ naghị agbaze na mmiri (0.010%).

Ndụ Nchekwa: Ọnwa iri abụọ na anọ

Ngwugwu: 25KG/ Akpa

Nchekwa: Emechiri emechi n'ebe kpọrọ nkụ na ebe ikuku na-abata

Tributyrinbụ triglyceride nwere molekul butyrate atọ e tinyere na glycerol, na-eme ka mkpokọta butyrate dịkwuo elu mgbe hydrolyzation gasịrị site na pancreas lipases.

Njirimara nke Tributyrin
Ọgbọ ọhụrụ nke butyrate-glycerol ester nke butyric acid.
Afọ na-agafe 100%.
Ọ bụrụ na e tinyere butyric acid n'ime obere eriri afọ, ọ dịghị mkpa ka e kpuchie ya.
A na-ahụ ya n'ime mmiri ara ehi na mmanụ aṅụ.

Ntụnyere n'etiti Tributyrin na Butyrate Nnu

Ọkara ndụ nke butyric acid bụ nkeji isii. Ọ na-esiri ike iru anụ ahụ na akụkụ ahụ ndị ọzọ dị n'èzí eriri afọ nke a na-enye n'ụdị butyric acid ma ọ bụ butyrate. Agbanyeghị, ọkara ndụ nke tributyrin bụ nkeji iri anọ, enwere ike idobe mkpokọta butyrate na plasma karịa 0.1mM maka awa 0.5-4 site n'ọnụ.

Usoro na Atụmatụ

Onye Na-eweta Ike

Dịka a maara nke ọma, butyric acid bụ abụba dị mkpụmkpụ nke bụ isi iyi ike nke mkpụrụ ndụ epithelial eriri afọ. Ihe karịrị 70% nke ike maka uto nke mkpụrụ ndụ epithelial eriri afọ bụ butyric acid na-enye. Agbanyeghị, tributyrin na-enye uru butyric acid kachasị elu nke na-ewepụta afọ ma e jiri ya tụnyere ngwaahịa butyrate ndị ọzọ.

Nchedo afọ

►Tributyrin na-akwalite mmụba na ọdịiche nke mkpụrụ ndụ epithelial mucosal mucosal, na-edozi mucosa mebiri emebi, ma na-agbasa ebe elu maka ịmịkọrọ ihe oriri.

►Tributyrin na-akwalite ngosipụta nke protein njikọ siri ike n'ime afọ, na-eme ka njikọ siri ike dị n'etiti mkpụrụ ndụ, na-egbochi macromolecules dịka nje bacteria na nsí ịbanye n'ahụ, ma na-eme ka ọrụ mgbochi anụ ahụ nke eriri afọ dịgide.

►Tributyrin na-akwalite mmepụta nke mucin (Muc) ma na-eme ka ọrụ mgbochi kemịkalụ eriri afọ sikwuo ike.

Ọkwa Ịlanarị Ka Mma

Tributyrin nwere ike ịkwalite mmepụta nke hemoglobin, melite ikike ibu oxygen, mee ka usoro nkwado ndụ dị n'ime ahụ sikwuo ike, ọ nwekwara ike imeziwanye ọrụ nke mitochondria ma kwalite mmepụta nke ATP, ihe ike nke na-akwalite ọrụ ndụ, iji melite ọnụego ndụ ma ọ bụ anụmanụ.

Ọgwụ Mgbochi na Ọgwụ Mgbochi

►Site na igbochi ọrụ nke NF-Kb, TNF-α na TLR, Tributyrin nwere ike ibelata mmebi ahụ.

►Tributyrin na-akwalite ngosipụta nke peptides nchebe endogenous, nke nwere ike iguzogide nje na nje virus n'ozuzu ya.