NchịkọtaEmere nnwale a iji mụọ mmetụta nke diludine nwere n'ịtọ ụmụaka na ịdị mma nke àkwá n'ime ọkụkọ na ụzọ isi mee ka mmetụta ya sikwuo ike site n'ịchọpụta ihe ndị dị na nha àkwá na serum. 1024 E kewara ọkụkọ ROM n'ime otu anọ nke ọ bụla gụnyere ihe anọ nke ọkụkọ 64 nke ọ bụla. Ndị otu ọgwụgwọ natara otu nri basal nke ejiri 0, 100, 150, 200 mg/kg diludine mee ihe n'otu n'otu maka ụbọchị 80. Nsonaazụ ya bụ ndị a. Mgbakwunye nke diludine na nri mere ka arụmọrụ nke ịkụ ọkụkọ dịkwuo mma, nke ọgwụgwọ 150 mg/kg kacha mma; ọnụego nke ịkwa akwa ya mụbara site na 11.8% (p< 0.01), mgbanwe nke àkwá belatara site na 10.36% (p< 0 01). Ibu àkwá mụbara ka mmụba nke diludine mụbara. Diludine belatara nke ukwuu njupụta uric acid n'ime ọbara (p< 0.01); itinye diludine belatara nke ukwuu n'ọbara Ca2+na ọdịnaya phosphate na-adịghị mma, yana mmụba nke ọrụ alkine phosphatase (ALP) nke serum (p< 0.05), yabụ o nwere mmetụta dị ukwuu na ibelata mgbawa àkwá (p<0.05) na nsogbu (p < 0.05); diludine mụbara elu albumen nke ukwuu. Uru Haugh (p <0.01), ọkpụrụkpụ shei na ibu shei (p< 0.05), 150 na 200mg/kg diludine belatakwara mkpokọta choleasterol na nkochi akwa (p< 0 05), mana mụbara ibu nkochi akwa (p < 0.05). Na mgbakwunye, diludine nwere ike ime ka ọrụ lipase (p < 0.01) ka mma, ma belata ọdịnaya nke triglyceride (TG3) (p< 0.01) na cholesterol (CHL) (p< 0 01) na serum, o belatara pasent nke abụba afọ (p< 0.01) na ọdịnaya abụba imeju (p< 0.01), nwee ikike igbochi ọkụkọ site na imeju abụba. Diludine mụbara ọrụ SOD dị na serum (p< 0 01) mgbe etinyere ya na nri ruo ihe karịrị ụbọchị 30. Agbanyeghị, ọ dịghị nnukwu ọdịiche dị na ọrụ GPT na GOT nke serum n'etiti otu njikwa na otu a gwọrọ. E chere na diludine nwere ike igbochi akpụkpọ ahụ nke mkpụrụ ndụ site na oxidation.
Isi okwuDiludine; ọkụkọ; SOD; cholesterol; triglyceride, lipase
Diludine bụ ihe mgbakwunye vitamin ọhụrụ nke na-egbochi oxidation ma na-arụ ọrụ nke ọma na mmetụta ya.[1-3]nke igbochi oxidation nke akpụkpọ ahụ dị ndụ na ime ka anụ ahụ nke mkpụrụ ndụ dị ndụ guzosie ike, wdg. Na afọ 1970, ọkachamara n'ọrụ ugbo nke Latvia na Soviet Union bụbu chọpụtara na diludine nwere mmetụta ya[4]nke ịkwalite uto nke anụ ọkụkọ na iguzogide oyi na ịka nká maka ụfọdụ osisi. A kọrọ na diludine anaghị akwalite uto nke anụmanụ, kamakwa ọ nwere ike ime ka arụmọrụ ọmụmụ nke anụmanụ ka mma ma melite ọnụego afọ ime, mmepụta nke mmiri ara ehi, mmepụta nke àkwá na ọnụego ịmụ nwa nke anụmanụ nwanyị.[1, 2, 5-7]A malitere ọmụmụ ihe banyere diludine na Chaịna site n'afọ 1980, ọtụtụ n'ime ọmụmụ ihe gbasara diludine na Chaịna bụ naanị maka ojiji ruo ugbu a, a kọkwara obere nnwale ole na ole gbasara ịkụ anụ ọkụkọ. Chen Jufang (1993) kọrọ na diludine nwere ike ime ka mmepụta àkwá na ibu nke àkwá anụ ọkụkọ ka mma, mana ọ baghị uru karịa.[5]ọmụmụ nke usoro ọrụ ya. Ya mere, anyị tinyere ọmụmụ ihe nhazi nke mmetụta na usoro ya n'ọrụ site n'inye ọkụkọ ndị na-edina ala nri na diludine, a kọkwara otu akụkụ nke nsonaazụ ugbu a dị ka ndị a:
Tebụl 1 Ihe mejupụtara na ihe ndị metụtara nri nnwale
%
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Nchịkọta nke nri Ihe ndị na-edozi ahụ
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Ọka 62 ME③ 11.97
Mkpụrụ agwa 20 CP 17.8
Nri azụ 3 Ca 3.42
Nri mkpụrụ rapeseed 5 P 0.75
Nri ọkpụkpụ 2 M et 0.43
Nri nkume 7.5 M na Cys 0.75
Methionine 0.1
Nnu 0.3
Multivitamin① 10
Ihe ndị dị na ya ② 0.1
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① Multivitamin: 11mg nke riboflavin, 26mg nke folic acid, 44mg nke oryzanin, 66mg nke niacin, 0.22mg nke biotin, 66mg nke B6, 17.6ug nke B12, 880mg nke choline, 30mg nke VK, 66IU nke VE, 6600ICU nke VDna 20000ICU nke VAa na-agbakwunye ya na kilogram ọ bụla nke nri ahụ; a na-agbakwunyekwa gram 10 nke multivitamin na kilogram 50 ọ bụla nke nri ahụ.
② Ihe ndị dị mkpa (mg/kg): A na-agbakwunye 60 mg nke Mn, 60mg nke Zn, 80mg nke Fe, 10mg nke Cu, 0.35mg nke I na 0.3mg nke Se na kilogram ọ bụla nke nri.
③ Nkeji nke ike a na-agbanwe agbanwe na-ezo aka na MJ/kg.
1. Ihe na usoro
1.1 Ihe nnwale
Beijing Sunpu Biochem. & Tech. Co., Ltd. kwesịrị inye diludine; anụmanụ nnwale ahụ ga-ezo aka na ọkụkọ ndị Rom na-etinye n'ahịa nke dị ụbọchị 300.
Nri nnwale: a ga-akwadebe nri nnwale nnwale dịka ọnọdụ dị n'ezie n'oge mmepụta ya dabere na ọkọlọtọ NRC, dịka egosiri na Tebụl 1.
1.2 Usoro nnwale
1.2.1 Nnwale inye nri: a ga-eme nnwale inye nri n'ugbo nke Ụlọ Ọrụ Hongji dị na Jiande City; a ga-ahọrọ ma kewaa ọkụkọ ndị Rom 1024 n'ime otu anọ n'enweghị usoro na nke ọ bụla maka iberibe 256 (a ga-emeghachi otu ọ bụla ugboro anọ, a ga-emekwa otu ọ bụla ugboro 64); a ga-enye ọkụkọ nri anọ nwere ọdịnaya dị iche iche nke diludine, a ga-agbakwunyekwa 0, 100, 150, 200mg/kg nke nri maka otu ọ bụla. A malitere ule ahụ na Eprel 10, 1997; ọkụkọ nwekwara ike ịchọta nri ma nara mmiri n'efu. A ga-edekọ nri nke otu ọ bụla na-eri, ọnụego itinye, mmepụta nke àkwá, àkwá gbajiri agbaji na ọnụọgụ nke àkwá na-adịghị mma. Ọzọkwa, ule ahụ kwụsịrị na June 30, 1997.
1.2.2 Ntụle nke ịdị mma nke àkwá: A ga-eme àkwá iri abụọ n'enweghị usoro mgbe emechara ule ahụ ruo ụbọchị anọ iji tụọ ihe ngosi metụtara ịdị mma nke àkwá, dịka nha nha nke àkwá, otu mkpụrụ haugh, ịdị arọ nke shei ahụ, ọkpụrụkpụ nke shei ahụ, nha nkochi ime akwa, wdg. Ọzọkwa, a ga-atụ ọdịnaya nke cholesterol dị na nkochi ime akwa site na iji usoro COD-PAP n'ihu ihe na-eme Cicheng nke Ningbo Cixi Biochemical Test Plant mepụtara.
1.2.3 Ntụle nke ihe ndị dị na serum biochemical index: A ga-ewere ọkụkọ ule iri na isii n'otu ọ bụla oge ọ bụla e mere ule ahụ ruo ụbọchị iri atọ na mgbe emechara ule ahụ iji kwadebe serum ahụ mgbe a tụchara ọbara ahụ site na akwara dị n'akụkụ nku ya. A ga-echekwa serum ahụ na obere okpomọkụ (-20℃) iji tụọ ihe ndị dị na biochemical index dị mkpa. A ga-atụ pasentị abụba afọ na ọdịnaya lipid imeju mgbe e gbuchara ma wepụ abụba afọ na imeju mgbe emechara nnwale ọbara.
A ga-eji usoro saturation tụọ superoxide dismutase (SOD) n'ihu ngwa reagent nke Beijing Huaqing Biochem. & Tech. Research Institute mepụtara. A ga-eji usoro U ricase-PAP tụọ uric acid (UN) dị na serum ahụ; a ga-eji usoro GPO-PAP tụọ triglyceride (TG3) n'ihu ngwa reagent Cicheng; a ga-eji nephelometry tụọ lipase ahụ; a ga-eji usoro Cicheng tụọ cholesterol zuru oke (CHL) n'ihu ngwa COD-PAP tụọ cholesterol zuru oke (CHL) n'ihu ngwa Cicheng reagent; a ga-eji usoro COD-PAP tụọ glutamic-pyruvic transaminase (GPT) tụọ glutamic-pyruvic transaminase (GPT) tụọ site na iji agba n'ihu ngwa Cicheng reagent; a ga-eji glutamic-oxalacetic transaminase (GOT) tụọ site na iji agba n'ihu ngwa Cicheng reagent; A ga-eji usoro ọnụego tụọ alkaline phosphatase (ALP) site na iji usoro ọnụego dị n'ihu ngwa Cicheng reagent; calcium ion (Ca2+) a ga-eji usoro methylthymol blue complexone tụọ serum ahụ n'ihu ngwa Cicheng reagent; a ga-eji usoro molybdate blue tụọ phosphorus inorganic (P) n'ihu ngwa Cicheng reagent.
2 Nsonaazụ ule
2.1 Mmetụta na arụmọrụ ịtọgbọ
A na-egosi arụmọrụ nke otu dị iche iche ejiri diludine hazie na Tebụl 2.
Tebụl 2: Arụmọrụ nke ọkụkọ e nyere nri basal nke e tinyere ọkwa diludine anọ
| Ọnụọgụ diludine a ga-agbakwunye (mg/kg) | ||||
| 0 | 100 | 150 | 200 | |
| Nri oriri (g) |  | |||
| Ọnụego ntinye (%) | ||||
| Ọkara ibu nke àkwá (g) | ||||
| Oke ihe na àkwá | ||||
| Ọnụọgụgụ àkwá gbajiri agbaji (%) | ||||
| Ọnụọgụgụ àkwá na-adịghị mma (%) | ||||
Site na Tebụl nke 2, a na-eme ka ọnụego nsị nke otu niile ejiri diludine mee ka ọ dịkwuo mma nke ọma, ebe mmetụta ya mgbe ejiri 150mg/kg mee ya kacha mma (ruo 83.36%), a na-emekwa ka 11.03% (p<0.01) ka mma ma e jiri ya tụnyere otu ntụaka; ya mere diludine nwere mmetụta nke ime ka ọnụego nsị dịkwuo mma. Site na nkezi ibu nke àkwá, ibu nke àkwá na-abawanye (p>0.05) yana mmụba nke diludine na nri kwa ụbọchị. Ma e jiri ya tụnyere otu ntụaka, ọdịiche dị n'etiti akụkụ niile edoziri nke otu ndị ejiri 200mg/kg nke diludine eme ihe apụtaghị ìhè mgbe a na-agbakwunye 1.79g nke oriri nri nkezi; Agbanyeghị, ọdịiche ahụ na-apụta ìhè nke ukwuu yana mmụba nke diludine, ọdịiche dị na oke nke ihe na àkwá n'etiti akụkụ ndị a na-edozi ahụ doro anya (p<0.05), mmetụta ya kacha mma mgbe 150mg/kg nke diludine ma bụrụ 1.25:1 nke a na-ebelata maka 10.36% (p<0.01) ma e jiri ya tụnyere otu ntụaka. Site na ọnụego àkwá gbajiri agbaji nke akụkụ niile a na-edozi, enwere ike ibelata ọnụego àkwá gbajiri agbaji (p<0.05) mgbe etinyere diludine na nri kwa ụbọchị; a na-ebelatakwa pasent nke àkwá na-adịghị mma (p<0.05) yana mmụba nke diludine.
2.2 Mmetụta dị na àgwà àkwá
Dịka e si hụ ya na Tebụl nke 3, ihe ngosi ọdịdị àkwá na ike ndọda nke àkwá anaghị emetụta (p>0.05) mgbe etinyere diludine na nri kwa ụbọchị, a na-amụbakwa ibu nke shei ahụ yana mmụba diludine agbakwunyere na nri kwa ụbọchị, ebe a na-amụba ibu nke shei ahụ maka 10.58% na 10.85% (p<0.05) n'otu n'otu ma e jiri ya tụnyere otu ntụaka mgbe etinyere 150 na 200mg/kg nke diludine; a na-amụba ọkpụrụkpụ nke shei àkwá ahụ yana mmụba diludine na nri kwa ụbọchị, ebe a na-amụba ọkpụrụkpụ nke shei àkwá ahụ maka 13.89% (p<0.05) mgbe etinyere 100mg/kg nke diludine ma e jiri ya tụnyere otu ntụaka, a na-amụbakwa ọkpụrụkpụ nke shei àkwá ahụ maka 19.44% (p<0.01) na 27.7% (p<0.01) n'otu n'otu mgbe etinyere 150 na 200mg/kg. A na-emeziwanye ihe dị na Haugh unit (p<0.01) nke ọma mgbe etinyere diludine, nke na-egosi na diludine nwere mmetụta nke ịkwalite mmepụta nke albumen dị arọ nke akwa ọcha. Diludine nwere ọrụ nke imeziwanye ihe dị na nkochi ime akwa, mana ọdịiche ahụ abụghị nke doro anya (p<0.05). Ihe dị na cholesterol nke nkochi ime akwa nke otu niile dị iche ma enwere ike ibelata ya nke ọma (p<0.05) mgbe etinyere 150 na 200mg/kg nke diludine. Ibu dị na nkochi ime akwa dị iche na ibe ha n'ihi ọnụọgụ diludine dị iche iche etinyere, ebe a na-emeziwanye ibu nke nkochi ime akwa maka 18.01% na 14.92% (p<0.05) mgbe 150mg/kg na 200mg/kg ma e jiri ya tụnyere otu ntụaka; ya mere, diludine kwesịrị ekwesị nwere mmetụta nke ịkwalite mmepụta nkochi ime akwa.
Tebụl 3 Mmetụta nke diludine nwere n'ịdị mma nke àkwá
| Ọnụọgụ diludine a ga-agbakwunye (mg/kg) | ||||
| Àgwà àkwá | 0 | 100 | 150 | 200 |
| Ndekọ ọdịdị àkwá (%) |  | |||
| Ike ndọda kpọmkwem maka àkwá (g/cm3) | ||||
| Ibu arọ nke shei àkwá (%) | ||||
| Ọkpụrụkpụ nke shei àkwá (mm) | ||||
| Nkeji eji aka (U) | ||||
| Ndepụta nkochi ime akwa (%) | ||||
| Kọlestrọl nke nkochi ime akwa (%) | ||||
| Ibu arọ nke nkochi akwa (%) | ||||
2.3 Mmetụta dị na pasentị abụba afọ na ọdịnaya nke abụba imeju nke ọkụkọ ndị na-edina
Lee Foto 1 na Foto 2 maka mmetụta nke diludine nwere na pasentị abụba afọ na ọdịnaya nke abụba imeju nke ọkụkọ ndị na-edina
Foto 1 Mmetụta nke diludine na pasentị nke abụba afọ (PAF) nke ọkụkọ ndị na-etinye aka
| Pasentị nke abụba afọ | |
| Ọnụọgụ diludine a ga-agbakwunye |
Foto nke 2 Mmetụta nke diludine nwere n'ime abụba imeju (LF) nke ọkụkọ ndị na-etinye aka
| Abụba imeju dị n'ime | |
| Ọnụọgụ diludine a ga-agbakwunye |
Dịka e si hụ ya na Foto 1, pasentị nke abụba afọ nke otu nnwale ahụ belatara ruo 8.3% na 12.11% (p<0.05) n'otu n'otu mgbe 100 na 150mg/kg nke diludine ma e jiri ya tụnyere otu ntụaka ahụ, a na-ebelata pasentị nke abụba afọ maka 33.49% (p<0.01) mgbe etinyere 200mg/kg nke diludine. Dịka e si hụ ya na Foto 2, a na-ebelata ọdịnaya abụba imeju (nke kpọrọ nkụ kpamkpam) site na 100, 150, 200mg/kg nke diludine n'otu n'otu maka 15.00% (p<0.05), 15.62% (p<0.05) na 27.7% (p<0.01) n'otu n'otu ma e jiri ya tụnyere otu ntụaka ahụ; Ya mere, diludine nwere mmetụta nke ibelata pasentị nke abụba afọ na abụba imeju nke ọdịnaya abụba dị n'ime ahụ, ebe mmetụta ya kacha mma mgbe etinyere 200mg/kg nke diludine.
2.4 Mmetụta na ndeksi biochemical nke serum
Site na Tebụl nke 4, ọdịiche dị n'etiti akụkụ ndị a na-eme n'oge ule SOD nke Nkebi nke Mbụ (30d) abụghị ihe doro anya, ihe nrịbama biochemical nke serum nke otu niile e tinyere diludine na Nkebi nke Abụọ (80d) nke ule ahụ dị elu karịa otu ntụaka (p<0.05). Enwere ike ibelata uric acid (p<0.05) na serum mgbe etinyere 150mg/kg na 200mg/kg nke diludine; ebe mmetụta (p<0.05) dị mgbe etinyere 100mg/kg nke diludine na Nkebi nke Mbụ. Diludine nwere ike ibelata triglyceride na serum, ebe mmetụta ya kacha mma (p<0.01) na otu ahụ mgbe etinyere 150mg/kg nke diludine na Nkebi nke Mbụ, ọ kacha mma na otu ahụ mgbe etinyere 200mg/kg nke diludine na Nkebi nke Abụọ. A na-ebelata mkpokọta cholesterol dị na serum yana mmụba nke diludine agbakwunyere na nri kwa ụbọchị, ọkachasị ihe dị na cholesterol zuru oke na serum na-ebelata ruo 36.36% (p<0.01) na 40.74% (p<0.01) n'otu n'otu mgbe etinyere 150mg/kg na 200mg/kg nke diludine na Nkebi nke Mbụ ma e jiri ya tụnyere otu ntụaka, ma belata maka 26.60% (p<0.01), 37.40% (p<0.01) na 46.66% (p<0.01) n'otu n'otu mgbe etinyere 100mg/kg, 150mg/kg na 200mg/kg nke diludine na Nkebi nke Abụọ ma e jiri ya tụnyere otu ntụaka. Ọzọkwa, a na-amụba ALP ka ọ na-abawanye na diludine na nri kwa ụbọchị, ebe uru nke ALP n'ime otu e tinyere 150mg/kg na 200mg/kg nke diludine dị elu karịa otu ntụaka (p<0.05) doro anya.
Tebụl 4 Mmetụta nke diludine na paramita serum
| Oke diludine a ga-agbakwunye (mg/kg) na Nkebi nke Mbụ (ụbọchị 30) nke ule ahụ | ||||
| ihe | 0 | 100 | 150 | 200 |
| Superoxide dismutase (mg/mL) |  | |||
| Asịd uric | ||||
| Triglyceride (mmol/L) | ||||
| Lipase (U/L) | ||||
| Kọlestrọl (mg/dL) | ||||
| Glutamic-pyruvic transaminase (U/L) | ||||
| Glutamic-oxalacetic transaminase (U/L) | ||||
| Alkaline phosphatase (mmol/L) | ||||
| Iọn calcium (mmol/L) | ||||
| phosphorus inorganic (mg/dL) | ||||
| Oke diludine a ga-agbakwunye (mg/kg) na Nkebi nke Abụọ (80d) nke ule ahụ | ||||
| ihe | 0 | 100 | 150 | 200 |
| Superoxide dismutase (mg/mL) |  | |||
| Asịd uric | ||||
| Triglyceride (mmol/L) | ||||
| Lipase (U/L) | ||||
| Kọlestrọl (mg/dL) | ||||
| Glutamic-pyruvic transaminase (U/L) | ||||
| Glutamic-oxalacetic transaminase (U/L) | ||||
| Alkaline phosphatase (mmol/L) | ||||
| Iọn calcium (mmol/L) | ||||
| phosphorus inorganic (mg/dL) | ||||
3 Nyocha na mkparịta ụka
3.1 Diludine dị na nnwale ahụ mere ka ọsọ nke ịkwa akwa dịkwuo mma, ibu nke àkwá, otu Haugh na ibu nke nkochi akwa dịkwuo mma, nke gosiri na diludine nwere mmetụta nke ịkwalite njikọta nke protein ahụ na ime ka mkpokọta nke albumen dị arọ nke akwa ọcha na protein nke nkochi akwa dịkwuo mma. Ọzọkwa, ọdịnaya nke uric acid dị na serum ahụ belatara nke ọma; a makwaara na mbelata ọdịnaya nke nitrogen na-abụghị protein na serum ahụ pụtara na ọsọ catabolism nke protein ahụ belatara, a na-egbukwa oge nchekwa nke nitrogen. Nsonaazụ a nyere ntọala maka ịbawanye njigide protein, kwalite itinye àkwá na ime ka ibu nke àkwá nke ọkụkọ ndị na-edina ụmụaka dịkwuo mma. Nsonaazụ nke nnwale ahụ gosiri na mmetụta itinye àkwá kacha mma mgbe etinyere 150mg/kg nke diludine, nke kwekọrọ na nsonaazụ ahụ.[6,7]nke Bao Erqing na Qin Shangzhi ma nweta ya site na itinye diludine na ngwụcha oge nke ọkụkọ. Mmetụta ya belatara mgbe ọnụọgụ diludine gafere 150mg/kg, nke nwere ike ịbụ n'ihi mgbanwe protein[8]Mmetụta ahụ metụtara n'ihi oke dose na oke ibu nke metabolism nke akụkụ ahụ na diludine.
3.2 Ọnụọgụgụ nke Ca2+E belatara n'ime ọbara nke àkwá na-amụ nwa, P dị na serum ahụ belatara na mbido, ọrụ ALP mụbara nke ọma n'ihu diludine, nke gosiri na diludine metụtara metabolism nke Ca na P n'ụzọ doro anya. Yue Wenbin kọrọ na diludine nwere ike ịkwalite mmịpụta[9] nke ihe ndị dị n'ime mineral Fe na Zn; ALP dịkarịsịrị n'anụ ahụ, dịka imeju, ọkpụkpụ, eriri afọ, akụrụ, wdg; ALP dị na serum sitere na imeju na ọkpụkpụ karịsịa; ALP dị n'ọkpụkpụ dị na osteoblast karịsịa ma nwee ike ijikọta ion phosphate na Ca2 site na serum mgbe mgbanwe gasịrị site n'ịkwalite ire ere nke phosphate na ịbawanye njupụta nke ion phosphate, a na-etinyekwa ya n'ọkpụkpụ n'ụdị hydroxyapatite, wdg iji mee ka Ca na P dị n'ime serum, nke kwekọrọ na mmụba nke ọkpụrụkpụ nke shei àkwá na ibu dị arọ nke shei àkwá na ihe ngosi àgwà akwa. Ọzọkwa, ọnụego àkwá gbajiri agbaji na pasent nke àkwá na-adịghị mma belatara nke ọma n'ihe gbasara arụmọrụ ịtọgbọ, nke kọwakwara isi ihe a.
3.3 E gosipụtara mbelata nke ọma na abụba afọ na imeju nke ọkụkọ ndị na-edina n'ime nri, nke gosiri na diludine nwere mmetụta nke igbochi mmepụta abụba n'ahụ. Ọzọkwa, diludine nwere ike imeziwanye ọrụ nke lipase na serum n'oge mbụ; a mụbara ọrụ nke lipase n'ime otu e tinyere 100mg/kg nke diludine, a belatakwara ọdịnaya nke triglyceride na cholesterol dị na serum (p<0.01), nke gosiri na diludine nwere ike ịkwalite mmebi nke triglyceride ma gbochie mmepụta nke cholesterol. Enwere ike igbochi ntinye abụba n'ihi na enzyme nke metabolism lipid dị na imeju.[10,11], na mbelata nke cholesterol n'ime nkochi akwa ahụ kọwakwara isi ihe a [13]. Chen Jufang kọrọ na diludine nwere ike igbochi mmepụta abụba n'ime anụmanụ ahụ ma melite pasent anụ ahụ dị nro nke broilers na ezi, ma nwee mmetụta nke ịgwọ imeju abụba. Nsonaazụ nke nnwale ahụ mere ka usoro a si arụ ọrụ doo anya, na nsonaazụ nke mwepụ na nlele nke ọkụkọ nnwale ahụ gosikwara na diludine nwere ike ibelata ọnụego imeju abụba nke ọkụkọ ndị na-edina n'ike n'ike.
3.4 GPT na GOT bụ ihe ngosi abụọ dị mkpa na-egosi ọrụ imeju na obi, imeju na obi nwekwara ike imebi ma ọ bụrụ na ọrụ ha dị oke elu. Agbanweghị ọrụ GPT na GOT na serum ahụ nke ọma mgbe etinyere diludine na nnwale ahụ, nke gosiri na imeju na obi emebighị; Ọzọkwa, nsonaazụ nha nke SOD gosiri na enwere ike imeziwanye ọrụ SOD na serum ahụ nke ọma mgbe ejiri diludine mee ihe ruo oge ụfọdụ. SOD na-ezo aka na ihe na-ewepụ isi ihe na-akpata superoxide free radical n'ahụ; ọ dị mkpa maka ịnọgide na-eguzosi ike n'ezi ihe nke akpụkpọ ahụ, imeziwanye ikike mgbochi ọrịa na ịnọgide na-enwe ahụike nke anụmanụ ahụ mgbe ọdịnaya SOD dị n'ahụ mụbara. Quh Hai, wdg. kọrọ na diludine nwere ike imeziwanye ọrụ nke 6-glucose phosphate dehydrogenase na akpụkpọ ahụ ma mee ka anụ ahụ sie ike [2] nke mkpụrụ ndụ ihe nketa. Sniedze kwuru na diludine gbochiri ọrụ [4] nke NADPH cytochrome C reductase mgbe ọ mụsịrị mmekọrịta dị n'etiti diludine na enzyme dị mkpa na NADPH kpọmkwem electron transfer yinye na microsome imeju oke. Ndị Odydents kwukwara na diludine nwere njikọ [4] na sistemụ oxidase mejupụtara na microsomal enzyme metụtara NADPH; na usoro nke diludine mgbe ọ banyere n'ime anụmanụ bụ ịrụ ọrụ nke iguzogide oxidation na ichekwa akpụkpọ ahụ dị ndụ [8] site na igbochi ọrụ nke electron transfer enzyme NADPH nke microsome na igbochi usoro peroxidation nke lipid compound. Nsonaazụ nnwale ahụ gosipụtara na ọrụ nchebe nke diludine na akpụkpọ ahụ dị ndụ site na mgbanwe nke ọrụ SOD ruo na mgbanwe nke ọrụ nke GPT na GOT ma gosipụta nsonaazụ ọmụmụ nke Sniedze na Odydents.
Ntụaka
1 Zhou Kai, Zhou Mingjie, Qin Zhongzhi, wdg. Ọmụmụ ihe gbasara diludine nke ime ka arụmọrụ ịmụ nwa nke atụrụ ka mmaJ. Ahịhịa naLivestock 1994 (2): 16-17
2 Qu Hai, Lv Ye, Wang Baosheng, Mmetụta nke diludine agbakwunyere na nri kwa ụbọchị na ọnụego afọ ime na ịdị mma nke mkpụrụ nwoke nke anụ oke bekee.J. Akwụkwọ akụkọ China nke Ọrụ Ugbo Oke bekee1994(6): 6-7
3 Chen Jufang, Yin Yuejin, Liu Wanhan, wdg. Nnwale nke itinye diludine n'ọrụ dị ka ihe mgbakwunye nriNnyocha Nri1993 (3): 2-4
4 Zheng Xiaozhong, Li Kelu, Yue Wenbin, wdg. Mkparịta ụka gbasara mmetụta ojiji na usoro nke ọrụ diludine dị ka onye na-akwalite uto ọkụkọNnyocha Nri1995 (7): 12-13
5 Chen Jufang, Yin Yuejin, Liu Wanhan, wdg. Nnwale nke itinye diludine n'ọrụ dị ka ihe mgbakwunye nriNnyocha Nri1993 (3): 2-5
6 Bao Erqing, Gao Baohua, Nnwale nke diludine maka ịzụ anụ ọhịa PekingNnyocha Nri1992 (7): 7-8
7 Qin Shangzhi Ule iji diludine mee ka ọkụkọ anụ dị iche iche na-arụ ọrụ nke ọma n'oge a na-etinye ha n'ọkwa dị elu.Akwụkwọ akụkọ Guangxi nke Ọrụ Ugbo Anụmanụ na Ọgwụ Anụmanụ1993.9(2): 26-27
8 Dibner J Jl Lvey FJ Protein Hepatic na amino acid metabolic n'ime anụ ọkụkọ Sayensị Anụ Ọkụkọ1990.69(7): 1188- 1194
9 Yue Wenbin, Zhang Jianhong, Zhao Peie, wdg. Ọmụmụ banyere itinye diludine na nkwadebe Fe-Zn na nri ọkụkọ na-eto eto kwa ụbọchị.Nri na Anụ Ụlọ1997, 18(7): 29-30
10 Mildner A na M, Steven D Clarke Porcine fatty acid synthase cloning nke DNA mgbakwunye, nkesa anụ ahụ nke itsmRNA na mgbochi nke ngosipụta site na somatotropin na protein nri J Nutri 1991, 121 900
11 W alzon RL Smon C, M orishita T, et a I Ọrịa ọbara ọgbụgba imeju buru ibu na ọkụkọ riri nri dị ọcha gabiga ókè Ọrụ enzyme ahọpụtara na histology imeju metụtara nsọpụrụ imeju na arụmọrụ ịmụpụtaSayensị Anụ ọkụkọ,1993 72(8): 1479-1491
12 Donaldson WE Mmeghachi omume nke imeju ọkụkọ na nriSayensị Anụ Ọkụkọ. 1990, 69(7): 1183-1187
13 Ksiazk ieu icz J. K ontecka H, H ogcw sk i L Ihe ndetu gbasara cholesterol ọbara dị ka ihe na-egosi abụba ahụ n'ime ọbọgwụAkwụkwọ akụkọ nke Sayensị Anụmanụ na Nri,1992, 1(3/4): 289-294
Oge ozi: Jun-07-2021
