Tributyrin (TB)naMonolaurin (GML)Dịka ihe mgbakwunye nri bara uru, ha nwere ọtụtụ mmetụta anụ ahụ na ịkọ ọkụkọ n'ime akwa, na-eme ka arụmọrụ mmepụta àkwá, ịdị mma àkwá, ahụike eriri afọ, na metabolism abụba dịkwuo mma. N'okpuru ebe a bụ ọrụ na usoro ha bụ isi:

1. Meziwanye arụmọrụ mmepụta àkwá
Glycerol monolauret(GML)

Itinye 0.15-0.45g/kg GML na nri ọkụkọ na-amụ nwa nwere ike ime ka ọnụego mmepụta àkwá dịkwuo elu nke ukwuu, belata ọnụego mgbanwe nri, ma mee ka nkezi ibu àkwá dịkwuo elu.
Nnyocha gosiri na 300-450mg/kg GML nwere ike ime ka ọnụego mmepụta àkwá nke ọkụkọ na-amụ nwa ka mma ma belata ọnụego nke àkwá nwere nkwarụ.

Tributyrin (TB) 

N'ime nnwale nke ọkụkọ broiler, 500mg/kg TB nwere ike igbu oge mbelata ọnụego mmepụta àkwá n'oge ikpeazụ nke ịkwa akwa, melite ike nke shei àkwá, ma belata ọnụego ịmụ nwa.
Ejikọtara ya naGML(dịka usoro e ji aka dee nke nwere ikike) nwere ike ịgbatịkwu oge mmepụta àkwá kachasị elu ma melite uru akụ na ụba.

2. Meziwanye mma akwa

Ọrụ nke GML
Mee ka protein dị elu, mee ka ha dị elu (HU), ma mee ka agba nkochi ime akwa dịkwuo mma.
Hazie ihe mejupụtara abụba abụba nke nkochi ime akwa, mụbaa polyunsaturated fatty acids (PUFA) na monounsaturated fatty acids (MUFA), ma belata ọdịnaya nke abụba juru eju (SFA).

Na dose nke 300mg/kg, GML mụbara ike nke ihe mkpuchi akwa na ọdịnaya protein ọcha nke akwa.

Ọrụ nkeTB

Mee ka ike nke ihe mkpuchi àkwá dịkwuo elu ma belata ọsọ nke mgbawa ihe mkpuchi (dịka ibelata 58.62-75.86% na nnwale).

Mee ka mkpụrụ ndụ ihe nketa ndị metụtara itinye calcium n'ime akpanwa (dịka CAPB-D28K, OC17) dịkwuo mma ma melite kalcium n'ime àkwá.

3. Ịhazi metabolism lipid na ọrụ antioxidant
Ọrụ nke GML
Belata triglycerides dị n'ọbara (TG), cholesterol zuru oke (TC), na cholesterol lipoprotein dị ala (LDL-C), ma belata ihe ndị na-etinye abụba n'afọ.
Meziwanye ọrụ nke serum superoxide dismutase (SOD) na glutathione peroxidase (GSH Px), belata ọdịnaya nke malondialdehyde (MDA), ma melite ikike antioxidant.
Ọrụ nkeTB
Belata ọdịnaya triglyceride imeju (10.2-34.23%) ma melite mkpụrụ ndụ ihe nketa metụtara oxidation abụba (dịka CPT1).
Belata ọkwa alkaline phosphatase (AKP) na MDA n'ime serum, ma mee ka ikike antioxidant zuru oke (T-AOC) dịkwuo elu.

4. Meziwanye ahụike eriri afọ
Ọrụ nke GML
Mee ka ogologo villus na oke villus ruo villus (V/C) nke jejunum dịkwuo mma iji melite ọdịdị eriri afọ.
Belata ihe ndị na-akpata mbufụt (dịka IL-1 β, TNF-α), mee ka ihe ndị na-egbochi mbufụt dịkwuo elu (dịka IL-4, IL-10), ma melite ọrụ mgbochi eriri afọ.
Mee ka usoro nke cecal microbiota dịkwuo mma, belata oke nke Proteobacteria, ma kwalite uto nke nje bacteria bara uru dịka Spirogyraceae.
Ọrụ nke TB
Gbanwee uru pH nke eriri afọ, kwalite mmụba nke nje bacteria bara uru (dịka lactobacilli), ma gbochie nje bacteria na-emerụ ahụ.
Mmelite nke protein njikọ tight (dịka Occludin, CLDN4) nke mkpụrụ ndụ ihe nketa na-eme ka ihe mgbochi eriri afọ dịkwuo mma.

5. Mmetụta njikwa ahụ ji alụso ọrịa ọgụ
Ọrụ nke GML
Meziwanye n'ọkwa splin na thymus index, mee ka ọrụ ahụ ji alụso ọrịa ọgụ ka mma.
Belata ihe nrịbama mkpali dị n'ọbara dịka aspartate aminotransferase (AST) na alanine aminotransferase (ALT).
Ọrụ nke TB
Belata mmeghachi omume mkpali eriri afọ site n'ịhazi ụzọ Toll-like receptor (TLR2/4).

6. Mmetụta itinye aka na nkwonkwo
Nnyocha ikike ikike egosila na njikọta nke GML na TB (dịka 20-40 TB+15-30 GML) nwere ike ime ka ọnụego mmepụta àkwá nke ọkụkọ na-amụ nwa dịkwuo mma (92.56% vs. 89.5%), belata mbufụt nke tube, ma mee ka oge mmepụta àkwá dị elu dịkwuo ogologo.

Nchịkọta:

Glycerol monolaurate (GML)naTributyrin (TB)nwere mmetụta ndị ọzọ na ọrụ ugbo ọkụkọ:

GMLna-elekwasị anya naime ka mma àkwá dịkwuo mma, ịchịkwa metabolism lipid, na ọrụ antioxidant;
TBna-elekwasị anya naimeziwanye ahụike eriri afọ na metabolism calcium;
Nchikota ahụ nwere ikemee ka mmepụta na àgwà àkwá dịkwuo mma, mee ka arụmọrụ mmepụta na ịdị mma nke àkwá dịkwuo mma.